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3,4-Dihydroxybenzylamine hydrobromide

CAS No. 16290-26-9

3,4-Dihydroxybenzylamine hydrobromide ( NSC 263475 hydrobromide )

Catalog No. M26024 CAS No. 16290-26-9

3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    3,4-Dihydroxybenzylamine hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
  • Description
    3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.(In Vitro):3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of all melanoma cell lines (IC50 = 100 μM) and the SK-MELB cell line (IC50 = 122 μM). The IC50 values are 30, 84,90, and 68 μM for Human SK-MEL-30, SK-MEL-2, SK-MEL-3,RPMI-7951 cells, respectively. 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) cytotoxicity in SK-MEL-2 and SK-MEL-28 cell lines can be enhanced by application of buthionine sulfoximine (BSO). BSO treatment sensitizes marginally pigmented cells to the effects of 3,4-DHBA, and the presence of decreses IC50 values of 3,4-DHBA by 127% in the SK-MEL-28 cell line and by 148% in the SK-MEL-2 cell line. 3,4-Dihydroxybenzylamine hydrobromide exhibits IC50values of 10, 25, 67, and 184 μM for S91A, S91B, L1210, and SCC-25 cells, respectively.(In Vivo):3,4-Dihydroxybenzylamine hydrobromide (200, 400, 600 and 800 mg/kg; i.p.; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days respectively. 3,4-Dihydroxybenzylamine hydrobromide (1000 mg/kg; i.p.; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose.
  • Synonyms
    NSC 263475 hydrobromide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    P450; protein tyrosine phosphatase(PTP); SETD8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    16290-26-9
  • Formula Weight
    220.1
  • Molecular Formula
    C7H10BrNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Br.NCc1ccc(O)c(O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liljebris C, et al. Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J Pharmacol Exp Ther. 2004 May;309(2):711-9.
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